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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NPAT All Species: 13.03
Human Site: S422 Identified Species: 31.85
UniProt: Q14207 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14207 NP_002510.2 1427 154291 S422 N F S Q I S T S I Q K K A F K
Chimpanzee Pan troglodytes XP_508739 1427 154232 S422 N F S Q I S T S I Q K K A F K
Rhesus Macaque Macaca mulatta XP_001104186 1427 154423 S421 N F S Q I S A S V Q K K A F K
Dog Lupus familis XP_546538 1450 156698 S431 H F S Q I G S S I Q K K A F K
Cat Felis silvestris
Mouse Mus musculus Q8BMA5 1420 152157 N416 L P Q E S Q E N F S Q I S S N
Rat Rattus norvegicus NP_001101617 1415 151589 P411 G N N H D V L P Q E S Q G N F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508521 1076 109024 N87 G A S C A L K N G G S D D R L
Chicken Gallus gallus XP_417161 1559 168410 R536 E Q L H G N C R L R K E A D V
Frog Xenopus laevis A2RRX6 1356 145650 H368 G V A T T S I H V A N D N L E
Zebra Danio Brachydanio rerio XP_690976 1310 139914 I322 T D D A I Q D I L A Q T E S D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 96.9 77.6 N.A. 74.8 74.3 N.A. 30.8 48.1 35.7 32.7 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.7 97.7 85.3 N.A. 83.8 83.4 N.A. 43.3 62.3 52.5 48.7 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 86.6 80 N.A. 0 0 N.A. 6.6 13.3 6.6 6.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 93.3 93.3 N.A. 26.6 20 N.A. 13.3 40 26.6 20 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 10 10 10 0 10 0 0 20 0 0 50 0 0 % A
% Cys: 0 0 0 10 0 0 10 0 0 0 0 0 0 0 0 % C
% Asp: 0 10 10 0 10 0 10 0 0 0 0 20 10 10 10 % D
% Glu: 10 0 0 10 0 0 10 0 0 10 0 10 10 0 10 % E
% Phe: 0 40 0 0 0 0 0 0 10 0 0 0 0 40 10 % F
% Gly: 30 0 0 0 10 10 0 0 10 10 0 0 10 0 0 % G
% His: 10 0 0 20 0 0 0 10 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 50 0 10 10 30 0 0 10 0 0 0 % I
% Lys: 0 0 0 0 0 0 10 0 0 0 50 40 0 0 40 % K
% Leu: 10 0 10 0 0 10 10 0 20 0 0 0 0 10 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 30 10 10 0 0 10 0 20 0 0 10 0 10 10 10 % N
% Pro: 0 10 0 0 0 0 0 10 0 0 0 0 0 0 0 % P
% Gln: 0 10 10 40 0 20 0 0 10 40 20 10 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 10 0 10 0 0 0 10 0 % R
% Ser: 0 0 50 0 10 40 10 40 0 10 20 0 10 20 0 % S
% Thr: 10 0 0 10 10 0 20 0 0 0 0 10 0 0 0 % T
% Val: 0 10 0 0 0 10 0 0 20 0 0 0 0 0 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _